Leptin and Interleukin-6 in End-stage Renal Disease
نویسندگان
چکیده
Objective: Leptin, the product of ob gene, is important in control of appetite in humans. The objective was to determine the pre and post serum leptin levels in patients with ESRD (undergoing hemodialysis), to compare the pre serum leptin levels in patients with ESRD and normal healthy controls and to determine the serum IL-6 levels among patients with ESRD before and after hemodialysis. Methodology: We measured the pre-and post dialysis leptin levels in hemodialysis patients (n=78) with end-stage renal disease (ESRD) with normal volunteers (n=78). Also plasma interleukin-6 was measured pre-and post dialysis in ESRD patients. Results: Mean serum leptin levels were significantly higher in ESRD patients than in normal control subjects (38.22 ± 6.25 vs. 7.1± 4.38ng/ml, respectively, P<0.01). Serum leptin post-dialysis levels were significantly greater than pre-dialysis levels (44. 78± 5.85 vs. 38.22± 6.25ng/ml, respectively, P<0.05). Post dialysis IL-6 levels was significantly greater than predialysis levels (14.7± 4.6 vs. 9± 4.9pg/ml, respectively, P<0.01). Conclusion: Kidney contributes to clearance of circulating leptin in humans. However, further studies are needed to evaluate the significance of these elevated leptin levels in patients with end-stage renal disease. KEYWORD: Leptin, Interleukin-6, ESRD Patients. Pak J Med Sci October December 2008 (Part-I) Vol. 24 No. 5 694-697 How to cite this article: Dashti N, Einollahi N, Nabatchian F. Leptin and Interleukin-6 in End-Stage Renal Disease. Pak J Med Sci 2008;24(5):694-97. 1. Nasrin Dashti, Ph.D 2. Nahid Einollahi, Ph.D 3. Fariba Nabatchian, Ph.D 1-3: School of Allied Health Medicine, Tehran University of Medical Sciences,
منابع مشابه
Avoidance of Dialysis in an End-Stage Renal Disease Patient Status-post Off-pump Coronary Artery Bypass Grafting
Certain benefits are clearly associated with the use of off-pump coronary artery bypass grafting (CABG) as compared with the on-pump CABG. The superiority is more evident in patients with multiple co morbidities including renal failure.We reviewed the medical records of a 67-year-old male with a past medical history that was significant for multiple cardiovascular diseases and new-onset end-sta...
متن کاملBardet-Biedl Syndrome with End Stage Renal Disease
Bardet-Biedl syndrome (BBS) is one of the rare autosomal recessive disorders that affect multiple organs of the body. The signs and symptoms of this condition vary among affected individuals, even among members of the same family. We present a case of BBS with features of hypogonadism and features such as marked central obesity, retinitis pigmentosa, polydactyly, renal abnormalities and mental ...
متن کاملDentomaxillofacial Radiographic Changes in a Group of Iranian Patients with End Stage Renal Disease Undergoing Hemodialysis
Introduction: This study aims to evaluate the dentomaxillofacial radiographic changes in end stage renal disease (ESRD) patients who were on hemodialysis. Methods: Parathyroid hormone (PTH), calcium, phosphorus and alkaline phosphatase (ALP) measurements, as well as Panoramic and periapical radiographs were obtained from seventy four patients with a history of end stage renal disease (ESRD). Re...
متن کاملPrevalence of cutaneous manifestations in end stage renal disease patients under hemodialysis in Imam Khomeini Hospital, Tehran in 2003
Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations in ESRD patients on maintenance hemodialysis in the dialysis department of Imam Khomeini ...
متن کاملPlasma immunoreactive leptin concentration in end-stage renal disease.
1. Leptin is thought to be an inhibitor of appetite. As the kidney helps clear several polypeptide hormones, plasma leptin may accumulate in end-stage renal disease. 2. Plasma immunoreactive leptin was measured in four groups of subjects: haemodialysis, continuous ambulatory peritoneal dialysis and renal transplant patients and a group of healthy controls. Leptin was also measured before and af...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008